Single-Cell Profiling Reveals Metabolic Reprogramming as a Resistance Mechanism in BRAF-Mutated Multiple Myeloma.

doi:10.1158/1078-0432.CCR-21-2040

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Article

Single-Cell Profiling Reveals Metabolic Reprogramming as a Resistance Mechanism in BRAF-Mutated Multiple Myeloma.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Dec 2021

Waldschmidt Johannes M, Kloeber Jake A, Anand Praveen, Frede Julia, Kokkalis Antonis, Dimitrova Valeriya, Potdar Sayalee, Nair Monica S, Vijaykumar Tushara, Im Nam Gyu, Guillaumet-Adkins Amy, Chopra Nitish, Stuart Hannah, Budano Lillian, Sotudeh Noori, Guo Guangwu, Grassberger Clemens, Yee Andrew J, Laubach Jacob P, Richardson Paul G, Anderson Kenneth C, Raje Noopur S, Knoechel Birgit, Lohr Jens G

Abstract excerpt

PURPOSE: Although remarkably effective in some patients, precision medicine typically induces only transient responses despite initial absence of resistance-conferring mutations. Using BRAF-mutated myeloma as a model for resistance to precision medicine we investigated if BRAF-mutated cancer cells have the ability to ensure their survival by rapidly adapting to BRAF inhibitor treatment. EXPERIMENTAL DESIGN:...

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Identifiers

PMID: 34518309
DOI: 10.1158/1078-0432.CCR-21-2040
PMCID: PMC8639639

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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