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Epithelial GREMLIN1 disrupts intestinal epithelial-mesenchymal crosstalk to induce a wnt-dependent ectopic stem cell niche through stromal remodelling

4 Jun 2025

Abstract excerpt

In homeostasis, counterbalanced morphogen signalling gradients along the vertical axis of the intestinal mucosa regulate the fate and function of epithelial and stromal cell compartments. Here, we use a disease-positioned mouse and human tissue to explore the consequences of pathological BMP signalling dysregulation on epithelial-mesenchymal interaction. Aberrant pan-epithelial expression of the secreted BMP...

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Cancer Cells and Metastasis
Genetic factors in colorectal cancer
Pancreatic and Hepatic Oncology Research

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 40467544
DOI: 10.1038/s41467-025-60364-6

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