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Article

Inactivation of Interferon Regulatory Factor 1 Causes Susceptibility to Colitis-Associated Colorectal Cancer.

Scientific reports - 11 Dec 2019

Jeyakumar Thiviya, Fodil Nassima, Van Der Kraak Lauren, Meunier Charles, Cayrol Romain, McGregor Kevin, Langlais David, Greenwood Celia M T, Beauchemin Nicole, Gros Philippe

Abstract excerpt

The mechanisms linking chronic inflammation of the gut (IBD) and increased colorectal cancer susceptibility are poorly understood. IBD risk is influenced by genetic factors, including the IBD5 locus (human 5q31), that harbors the IRF1 gene. A cause-to-effect relationship between chronic inflammation and colorectal cancer, and a possible role of IRF1 were studied in Irf1-/- mice in a model of colitis-associated...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 31827213
DOI: 10.1038/s41598-019-55378-2
PMCID: PMC6906452

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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