Article
A review of standardized high-throughput cardiovascular phenotyping with a link to metabolism in mice.
Mammalian genome : official journal of the International Mammalian Genome Society - 1 Jun 2023
Lindovsky Jiri, Nichtova Zuzana, Dragano Nathalia R V, Pajuelo Reguera David, Prochazka Jan, Fuchs Helmut, Marschall Susan, Gailus-Durner Valerie, Sedlacek Radislav, Hrabě de Angelis Martin, Rozman Jan, Spielmann Nadine
Abstract excerpt
Cardiovascular diseases cause a high mortality rate worldwide and represent a major burden for health care systems. Experimental rodent models play a central role in cardiovascular disease research by effectively simulating human cardiovascular diseases. Using mice, the International Mouse Phenotyping Consortium (IMPC) aims to target each protein-coding gene and phenotype multiple organ systems in single-gene...
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