Article

Loss of cardiac PFKFB2 drives Metabolic, Functional, and Electrophysiological Remodeling in the Heart

2023-11-23

Abstract excerpt

<h4>Background</h4> Phosphofructo-2-kinase/fructose-2,6-bisphosphatase (PFK-2) is a critical glycolytic regulator responsible for upregulation of glycolysis in response to insulin and adrenergic signaling. PFKFB2, the cardiac isoform of PFK-2, is degraded in the heart in the absence of insulin signaling, contributing to diabetes-induced cardiac metabolic inflexibility. However, previous studies have not examined...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 05f71e51-d0ec-5236-88be-bc1547296483
DOI: 10.1101/2023.11.22.568379

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Loss of cardiac PFKFB2 drives Metabolic, Functional, and Electrophysiological Remodeling in the HeartDOI 10.1101/2023.11.22.568379Read

Cardiac phosphatase-deficient 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase increases glycolysis, hypertrophy, and myocyte resistance to hypoxia.Semantic proximity Read

Exercise-Induced Changes in Glucose Metabolism Promote Physiological Cardiac Growth.Semantic proximity Read

Afterload-induced Decreases in Fatty Acid Oxidation Develop Independently of Increased Glucose UtilizationSemantic proximity Read

Shared and Divergent Features of Cardiac Transcriptome and Glucose Metabolism Markers in Human and Mouse HFpEFSemantic proximity Read

Obesity and diabetes related disturbances in systemic metabolism induce a cardiometabolic heart failure with preserved ejection fraction phenotype in a combined high-fat, high sucrose diet and streptozotocin mouse modelSemantic proximity Read

Transcriptome Data Analysis of Primary Cardiomyopathies Reveals Perturbations in Arachidonic Acid MetabolismSemantic proximity Read

Cardiac Dysfunction and Metabolic Inflexibility in a Mouse Model of Diabetes Without Dyslipidemia.Semantic proximity Read

Metabolic inflexibility across heart failure phenotypes: mechanisms and type-specific therapeutic implications.Semantic proximity Read

Hepatic Ketogenesis Attenuates Cardiac Hypertrophy via Metabolic ReprogrammingSemantic proximity Read

Identification of Differentially Expressed Genes and Processes in Myocardial Tissue of Liver-Specific Gck Knockout MiceSemantic proximity Read

Molecular Signature of HFpEFSemantic proximity Read

Plakophilin-2 Coordinates Energy Metabolism and Contractility in Cardiomyocytes, Revealing Its Roles beyond DesmosomesSemantic proximity Read