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A multi-step immune-competent genetic mouse model reveals phenotypic plasticity in uveal melanoma

2025-06-07

Abstract excerpt

<h4>ABSTRACT</h4> Uveal melanoma (UM) is a highly aggressive intraocular malignancy with limited therapeutic options for metastatic disease. Existing transgenic UM mouse models inadequately recapitulate human disease progression, while transplant models lack immune competence for studying the tumor immune microenvironment and therapeutic interventions. To address these limitations, we developed a genetically engi...

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Literature Corpus work
ca3ef2c7-545a-51bc-be55-aa633c811355
DOI
10.1101/2025.06.04.657841
Open publication

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