Article

Novel CRISPR-Cas9 BAP1 Knockout Pre-Clinical Tumor Model Recapitulates Human Melanoma Tumorigenesis and Immune Evolution

2025-04-15

Abstract excerpt

<title>Abstract</title> <p>BAP1-deficient melanocytic tumors exhibit strong immunosuppressive features and poor prognosis. Currently, no immune-competent preclinical models exist to study their tumor-immune interactions or test new immunotherapies. This limitation hinders progress in understanding how BAP1 loss drives tumor aggressiveness and immune evasion. To address this, we generated a syngeneic BAP1 knockout...

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Literature Corpus work: dd5a706d-ab69-5f81-8c3e-9f1af7996af9
DOI: 10.21203/rs.3.rs-6134890/v2

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