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Article

Uveal melanoma driver mutations in GNAQ/11 yield numerous changes in melanocyte biology.

Pigment cell & melanoma research - 1 Sept 2018

Perez Dahlia E, Henle Andrea M, Amsterdam Adam, Hagen Hannah R, Lees Jacqueline A

Abstract excerpt

Uveal melanoma (UM) is the most common primary intraocular cancer and has a high incidence of metastasis, which lacks any effective treatment. Here, we present zebrafish models of UM, which are driven by melanocyte-specific expression of activating GNAQ or GNA11 alleles, GNAQ/11Q209L , the predominant initiating mutations for human UM. When combined with mutant tp53, GNAQ/11Q209L transgenics develop various...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Open in PubMed Open full text

Identifiers

PMID: 29570931
DOI: 10.1111/pcmr.12700
PMCID: PMC6151293

Genes

GNAQ
GNA11

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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