Dynamic changes of genomic and transcriptomic tumor diversity during melanoma progression

Abstract excerpt

Metastatic melanoma is an aggressive disease that is notoriously difficult to treat. Here, we used a BRAF V600E -driven mouse model to study melanoma progression and metastasis in the absence of extrinsic mutagenic factors such as UV radiation. The tumors were grown for different time periods in seven different mice such that disease progression was tracked over time. We sequenced the whole exome and whole transc...

Topics

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• Antigens, Neoplasm
• Biological Variation, Population
• Chemokines
• Melanoma, Experimental
• Precision Medicine
• Receptors, Antigen, T-Cell
• RNA-Seq
• Tumor Microenvironment

Identifiers and source

Literature Corpus work

fe6020fc-4f03-5c69-b700-227c3498723b

DOI

10.1101/2021.03.18.435947