Article
Mouse Cutaneous Melanoma Induced by Mutant BRaf Arises from Expansion and Dedifferentiation of Mature Pigmented Melanocytes.
Cell stem cell - 2 Nov 2017
Köhler Corinna, Nittner David, Rambow Florian, Radaelli Enrico, Stanchi Fabio, Vandamme Niels, Baggiolini Arianna, Sommer Lukas, Berx Geert, van den Oord Joost J, Gerhardt Holger, Blanpain Cedric, Marine Jean-Christophe
Abstract excerpt
To identify the cells at the origin of melanoma, we combined single-cell lineage-tracing and transcriptomics approaches with time-lapse imaging. A mouse model that recapitulates key histopathological features of human melanomagenesis was created by inducing a BRafV600E-driven melanomagenic program in tail interfollicular melanocytes. Most targeted mature, melanin-producing melanocytes expanded clonally within the...
Topics
- Animals
- Biomarkers
- Carcinogenesis
- Cell Dedifferentiation
- Cell Proliferation
- Dermis
- Hair Follicle
- Humans
- Melanocytes
- Melanoma
- Mice
- Mutation
- Neoplasm Invasiveness