A Multistep Immune-Competent Genetically Engineered Mouse Model Reveals Phenotypic Plasticity in Uveal Melanoma.

doi:10.1158/0008-5472.CAN-25-2684

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A Multistep Immune-Competent Genetically Engineered Mouse Model Reveals Phenotypic Plasticity in Uveal Melanoma.

Cancer research - 4 Aug 2026

Xu Xiaonan, Liu Xiaoxian, Jarajapu Vinesh, Neelature Sriramareddy Sathya, Konecny Filip, Posorske Benjamin, Dollar James J, Liu Xiao, Jasani Neel, Wang Kaizhen, Mecozzi Nicol, Soto-Vargas Zulaida, Ochoa-Rios Shaaron L, Murikipudi Harini, Phan Nhan, Chadourne Manon, Kuznetsoff Jeffim N, Sinard John, Bennett Richard L, Licht Jonathan D, Smalley Keiran S M, Harbour J William, Yu Xiaoqing, Karreth Florian A

Abstract excerpt

Uveal melanoma is a highly aggressive intraocular malignancy with limited therapeutic options for metastatic disease. Existing transgenic uveal melanoma mouse models inadequately recapitulate human disease progression, whereas transplant models lack immune competence for studying the tumor immune microenvironment and therapeutic interventions. To address these limitations, we developed a genetically engineered...

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Identifiers

PMID: 41661679
DOI: 10.1158/0008-5472.CAN-25-2684
PMCID: PMC12974268

Genes

MYC
BAP1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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