Article

Impaired proteasome induces mitochondrial DNA release to activate the cGAS-STING signaling pathway and cause necroptosis in mouse brain

2024-11-14

Abstract excerpt

Impaired proteasome function is consistently associated with many neurodegenerative disorders, including Alzheimer’s disease (AD), showing neuroinflammation and neurodegeneration; however, how impaired proteasome causes neuroinflammation and neuronal death remains less understood. Here, we studied the effect of impaired proteasome on neuroinflammation and neuronal death in a knockout (KO) mouse model with reduced...

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Literature Corpus work: 4fd4fab5-d988-5159-8412-8f78563f374e
DOI: 10.1101/2024.11.13.623442

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Impaired proteasome induces mitochondrial DNA release to activate the cGAS-STING signaling pathway and cause necroptosis in mouse brainDOI 10.1101/2024.11.13.623442Read

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