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Article

HNE produced by the malaria parasite<i>Plasmodium falciparum</i>generates HNE–protein adducts and decreases erythrocyte deformability

18 Jan 2007

Abstract excerpt

In Plasmodium falciparum-parasitized erythrocytes, hemozoin (HZ) formation was accompanied by enhanced formation of 4-hydroxynonenal (HNE)-protein adducts on the cell surface, reaching in the HZ-rich schizont forms the 16.8-fold amount of control non-parasitized cells. The addition of 1-100 microM exogenous HNE to control non-parasitized cells generated HNE-adducts on surface proteins in amounts similar to those...

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PMID: 17263914
DOI: 10.1179/135100007x162284

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