Article

Deficiency of metabolic regulator PKM2 activates the pentose phosphate pathway and generates TCF1+ progenitor CD8+ T cells to improve checkpoint blockade

2023-09-21

Abstract excerpt

<title>Abstract</title> TCF1high progenitor CD8+ T cells mediate the efficacy of PD-1 blockade, however the mechanisms that govern their generation and maintenance are poorly understood. Here, we show that targeting glycolysis through deletion of pyruvate kinase muscle 2 (PKM2) results in elevated pentose phosphate pathway (PPP) activity, leading to enrichment of a TCF1high central memory...

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Literature Corpus work: c9eeb240-4537-5148-a627-12014c89df3f
DOI: 10.21203/rs.3.rs-3356477/v1

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Deficiency of metabolic regulator PKM2 activates the pentose phosphate pathway and generates TCF1+ progenitor CD8+ T cells to improve checkpoint blockadeDOI 10.21203/rs.3.rs-3356477/v1Read

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