Article

Contrasting Broad- and Clinically- defined Polygenic Indicators of Depression and Depression-related Phenotypes in Adults and Children

2020-08-28

Abstract excerpt

<p>Twin studies indicate that 30-40% of the disease liability for depression can be attributed to genetic differences. Here, we assess the explanatory ability of polygenic scores (PGS) based on broad- (PGSBD) and clinical- (PGSMDD) depression summary statistics from the UK Biobank using a sample of adults (N=210; 100% European Ancestry) who have been extensively phenotyped for depression and related neurocognitive...

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Literature Corpus work: c9e8f30a-b912-527c-9435-6b2ff9595ceb
DOI: 10.31234/osf.io/pn9vb

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