Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A cross-disorder PRS-pheWAS of 5 major psychiatric disorders in UK Biobank.

PLoS genetics - 1 May 2020

Leppert Beate, Millard Louise A C, Riglin Lucy, Davey Smith George, Thapar Anita, Tilling Kate, Walton Esther, Stergiakouli Evie

Abstract excerpt

Psychiatric disorders are highly heritable and associated with a wide variety of social adversity and physical health problems. Using genetic liability (rather than phenotypic measures of disease) as a proxy for psychiatric disease risk can be a useful alternative for research questions that would traditionally require large cohort studies with long-term follow up. Here we conducted a hypothesis-free phenome-wide...

Topics

Join the communities discussing this publication.

Attention Deficit Disorder with Hyperactivity
Autism Spectrum Disorder
Biological Specimen Banks
Bipolar Disorder
Depressive Disorder, Major

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Genetic Heterogeneity

Mental Disorders

Socioeconomic Factors

Source

Open in PubMed Open full text

Identifiers

PMID: 32392212
DOI: 10.1371/journal.pgen.1008185
PMCID: PMC7274459

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A cross-disorder PRS-pheWAS of 5 major psychiatric disorders in UK Biobank.PMID 32392212Read ↗

A cross-disorder MR-pheWAS of 5 major psychiatric disorders in UK BiobankSemantic proximity Read ↗

Polygenic risk of psychiatric disorders exhibits cross-trait associations in electronic health record dataSemantic proximity Read ↗

Application of polygenic scores to a deeply phenotyped sample enriched for substance use disorders reveals extensive pleiotropy with psychiatric and somatic traits.Semantic proximity Read ↗

Application of polygenic scores to a deeply phenotyped sample enriched for substance use disorders reveals extensive pleiotropy with psychiatric and medical traitsSemantic proximity Read ↗

Genetic predisposition to psychiatric disorders and risk of COVID-19Semantic proximity Read ↗

Analysis of genetic differences between psychiatric disorders: exploring pathways and cell types/tissues involved and ability to differentiate the disorders by polygenic scores.Semantic proximity Read ↗

Polygenic Risk of Psychiatric Disorders Exhibits Cross-trait Associations in Electronic Health Record Data From European Ancestry Individuals.Semantic proximity Read ↗

Structure of the Genetic Risks for Psychiatric Disorders in Swedish Population-Based Registries.Semantic proximity Read ↗

Association of Polygenic Liabilities for Major Depression, Bipolar Disorder, and Schizophrenia With Risk for Depression in the Danish PopulationSemantic proximity Read ↗

Genetic risk modeling approaches to resolve phenotypic and molecular heterogeneity in psychiatric disorders.Semantic proximity Read ↗

Polygenic Scores and Environmental Factors in Psychiatric Disorders: Gene–Environment Interaction Analyses Using the iPSYCH StudySemantic proximity Read ↗

Polygenic Scores and Environmental Factors in Psychiatric Disorders: Gene–Environment Interaction Analyses Using the iPSYCH StudySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.