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Article

Polygenic Risk Scores Derived From Varying Definitions of Depression and Risk of Depression.

JAMA psychiatry - 1 Oct 2021

Mitchell Brittany L, Thorp Jackson G, Wu Yeda, Campos Adrian I, Nyholt Dale R, Gordon Scott D, Whiteman David C, Olsen Catherine M, Hickie Ian B, Martin Nicholas G, Medland Sarah E, Wray Naomi R, Byrne Enda M

Abstract excerpt

Importance: Genetic studies with broad definitions of depression may not capture genetic risk specific to major depressive disorder (MDD), raising questions about how depression should be operationalized in future genetic studies. Objective: To use a large, well-phenotyped single study of MDD to investigate how different definitions of depression used in genetic studies are associated with estimation of MDD and...

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Identifiers

PMID: 34379077
DOI: 10.1001/jamapsychiatry.2021.1988
PMCID: PMC8358814

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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