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Article

Associating broad and clinically defined polygenic scores for depression with depression-related phenotypes.

Scientific reports - 21 Apr 2023

McGeary John E, Benca-Bachman Chelsie E, Risner Victoria A, Beevers Christopher G, Gibb Brandon E, Palmer Rohan H C

Abstract excerpt

Twin studies indicate that 30-40% of the disease liability for depression can be attributed to genetic differences. Here, we assess the explanatory ability of polygenic scores (PGS) based on broad- (PGSBD) and clinical- (PGSMDD) depression summary statistics from the UK Biobank in an independent sample of adults (N = 210; 100% European Ancestry) who were extensively phenotyped for depression and related...

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Identifiers

PMID: 37085695
DOI: 10.1038/s41598-023-33645-7
PMCID: PMC10121555

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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