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Article

Histamine Transmission Modulates the Phenotype of Murine Narcolepsy Caused by Orexin Neuron Deficiency.

PloS one - 1 Jan 2015

Bastianini Stefano, Silvani Alessandro, Berteotti Chiara, Lo Martire Viviana, Cohen Gary, Ohtsu Hiroshi, Lin Jian-Sheng, Zoccoli Giovanna

Abstract excerpt

Narcolepsy type 1 is associated with loss of orexin neurons, sleep-wake derangements, cataplexy, and a wide spectrum of alterations in other physiological functions, including energy balance, cardiovascular, and respiratory control. It is unclear which narcolepsy signs are directly related to the lack of orexin neurons or are instead modulated by dysfunction of other neurotransmitter systems physiologically...

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PMID: 26474479
DOI: 10.1371/journal.pone.0140520
PMCID: PMC4608736

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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