Article

FinaleMe: Predicting DNA methylation by the fragmentation patterns of plasma cell-free DNA

2024-01-02

Abstract excerpt

Analysis of DNA methylation in cell-free DNA (cfDNA) reveals clinically relevant biomarkers but requires specialized protocols and sufficient input material that limits its applicability. Millions of cfDNA samples have been profiled by genomic sequencing. To maximize the gene regulation information from the existing dataset, we developed FinaleMe, a non-homogeneous Hidden Markov Model (HMM), to predict DNA methyla...

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Literature Corpus work: ead96e92-ad8c-5f9a-9161-4e62bb70e768
DOI: 10.1101/2024.01.02.573710

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