Article
The antibody zalutumumab inhibits epidermal growth factor receptor signaling by limiting intra- and intermolecular flexibility.
Proceedings of the National Academy of Sciences of the United States of America - 22 Apr 2008
Lammerts van Bueren Jeroen J, Bleeker Wim K, Brännström Annika, von Euler Anne, Jansson Magnus, Peipp Matthias, Schneider-Merck Tanja, Valerius Thomas, van de Winkel Jan G J, Parren Paul W H I
Abstract excerpt
The epidermal growth factor receptor (EGFR) activates cellular pathways controlling cell proliferation, differentiation, migration, and survival. It thus represents a valid therapeutic target for treating solid cancers. Here, we used an electron microscopy-based technique (Protein Tomography) to study the structural rearrangement accompanying activation and inhibition of native, individual, EGFR molecules....
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