Article

In vivo regulation of infected and bystander monocyte phenotype by the Mycobacterium marinum ESX-1 type VII secretion system

2024-10-16

Abstract excerpt

<title>Abstract</title> Pathogenic mycobacteria require the conserved ESX-1 type VII secretion system to cause disease. Using a murine Mycobacterium marinum infection model we recently demonstrated an antagonistic interplay between neutrophils and monocytes, where monocytes play a host-protective role by restricting ESX-1-dependent intragranuloma accumulation of neutrophils. Here, we demonstrate that the prote...

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Literature Corpus work: c99649bb-33cb-5ce0-9a23-9f751c65e110
DOI: 10.21203/rs.3.rs-4999318/v1

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