Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The ESX-5 Secretion System of <i>Mycobacterium marinum</i> Modulates the Macrophage Response

1 Nov 2008

Abstract excerpt

The ESX-5 secretion system of pathogenic mycobacteria is responsible for the secretion of various PPE and PE-PGRS proteins. To better understand the role of ESX-5 effector proteins in virulence, we analyzed the interactions of Mycobacterium marinum ESX-5 mutant with human macrophages (Mphi). Both wild-type bacteria and the ESX-5 mutant were internalized and the ESX-5 mutation did not affect the escape of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Immune Response and Inflammation
Share to Mycobacterium research and diagnosis
Share to Tuberculosis Research and Epidemiology

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 18981138
DOI: 10.4049/jimmunol.181.10.7166

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The ESX-5 Secretion System of <i>Mycobacterium marinum</i> Modulates the Macrophage ResponsePMID 18981138Read ↗

Mycobacterial Secretion Systems ESX-1 and ESX-5 Play Distinct Roles in Host Cell Death and Inflammasome ActivationSemantic proximity Read ↗

PPE and PE_PGRS proteins of <i>Mycobacterium marinum</i> are transported via the type VII secretion system ESX‐5Semantic proximity Read ↗

The loss of the PDIM/PGL virulence lipids causes differential secretion of ESX-1 substrates in <i>Mycobacterium marinum</i>Semantic proximity Read ↗

The regulatory functions of ESX-1 substrates, EspE and EspF, are separable from secretionSemantic proximity Read ↗

ESX secretion system: The gatekeepers of mycobacterial survivability and pathogenesisSemantic proximity Read ↗

Disruption of the ESX‐5 system of <i>Mycobacterium tuberculosis</i> causes loss of PPE protein secretion, reduction of cell wall integrity and strong attenuationSemantic proximity Read ↗

The ESX-5 System of Pathogenic Mycobacteria Is Involved In Capsule Integrity and Virulence through Its Substrate PPE10Semantic proximity Read ↗

A Small Protein but with Diverse Roles: A Review of EsxA in Mycobacterium–Host InteractionSemantic proximity Read ↗

The C terminus of the mycobacterium ESX-1 secretion system substrate ESAT-6 is required for phagosomal membrane damage and virulenceSemantic proximity Read ↗

EspH is a hypervirulence factor for Mycobacterium marinum and essential for the secretion of the ESX-1 substrates EspE and EspFSemantic proximity Read ↗

Intra-granuloma accumulation and inflammatory differentiation of neutrophils underlie mycobacterial ESX-1-mediated immunopathologySemantic proximity Read ↗

Integrated transcriptomic and proteomic analysis of pathogenic mycobacteria and their esx-1 mutants reveal secretion-dependent regulation of ESX-1 substrates and WhiB6 as a transcriptional regulatorSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.