Article

Interplay between T-bet and HIF-1a is required for proper epigenomic and transcriptomic reprogramming of monocyte subsets

2024-06-20

Abstract excerpt

<title>Abstract</title> <p><bold>Background:</bold> Monocyte subsets, classified into classical, intermediate, and non-classical, have distinct specific functions. Despite increasing reports describing changes in monocyte subsets in a wide range of pathological inflammatory conditions, such as autoimmune and infectious diseases, the regulatory mechanisms underlying their differentiation are poorly understood. Thi...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: a14fef6e-dd0b-5308-9feb-da1e45849cb5
DOI: 10.21203/rs.3.rs-4526525/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Interplay between T-bet and HIF-1a is required for proper epigenomic and transcriptomic reprogramming of monocyte subsetsDOI 10.21203/rs.3.rs-4526525/v1Read

Epigenetic and transcriptomic reprogramming in monocytes of severe COVID-19 patients reflects alterations in myeloid differentiation and the influence of inflammatory cytokinesSemantic proximity Read

Single-cell transcriptome analysis reveals the dysregulated monocyte state associated with tuberculosis progressionSemantic proximity Read

Comparative analysis of neutrophil and monocyte epigenomesSemantic proximity Read

Major Contribution of Myeloid Cells In TB specific Host Gene Signature: Revelations from Re-Analysis of Publicly Available DatasetsSemantic proximity Read

Divergent Epigenetic and Transcriptomic Reprogramming of Monocyte Subpopulations in Systemic Lupus ErythematosusSemantic proximity Read

Single-cell multimodal profiling of monocytes reveals diverse phenotypes and alterations linked to cardiovascular disease risksSemantic proximity Read

<i>Mycobacterium tuberculosis</i>-dependent Monocyte Expression Quantitative Trait Loci and Tuberculosis PathogenesisSemantic proximity Read

Monocyte transcriptome signatures of inflammation and enhanced neutrophil recruitment characterize immunopathology in the blood of tuberculosis patientsSemantic proximity Read

Epigenetics and Proteomics Join Transcriptomics in the Quest for Tuberculosis BiomarkersSemantic proximity Read

Mycobacterium tuberculosis-dependent monocyte expression quantitative trait loci, cytokine production, and TB pathogenesisSemantic proximity Read

An evolutionary recent IFN/IL-6/CEBP axis is linked to monocyte expansion and tuberculosis severity in humansSemantic proximity Read