Article

Intra-granuloma accumulation and inflammatory differentiation of neutrophils underlie mycobacterial ESX-1-mediated immunopathology

2022-01-20

Abstract excerpt

The conserved ESX-1 type VII secretion system is a major virulence determinant of pathogenic mycobacteria, including Mycobacterium tuberculosis and Mycobacterium marinum . ESX-1 is known to interact with infected macrophages, but its potential roles in regulating other host cells and immunopathology have remained largely unexplored. Using a murine M. marinum infection model we identify neutrophils and Ly6C + M...

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Literature Corpus work: e7e385af-3943-52cf-93f9-cb8fe6d29c03
DOI: 10.1101/2022.01.19.477031

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