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Host-Detrimental Role of Esx-1-Mediated Inflammasome Activation in Mycobacterial Infection

6 May 2010

Abstract excerpt

The Esx-1 (type VII) secretion system is a major virulence determinant of pathogenic mycobacteria, including Mycobacterium marinum. However, the molecular events and host-pathogen interactions underlying Esx-1-mediated virulence in vivo remain unclear. Here we address this problem in a non-lethal mouse model of M. marinum infection that allows detailed quantitative analysis of disease progression. M. marinum...

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PMID: 20463815
DOI: 10.1371/journal.ppat.1000895

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