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Article

Genomic Characterization of Murine Monocytes Reveals C/EBPβ Transcription Factor Dependence of Ly6C- Cells.

Immunity - 16 May 2017

Mildner Alexander, Schönheit Jörg, Giladi Amir, David Eyal, Lara-Astiaso David, Lorenzo-Vivas Erika, Paul Franziska, Chappell-Maor Louise, Priller Josef, Leutz Achim, Amit Ido, Jung Steffen

Abstract excerpt

Monocytes are circulating, short-lived mononuclear phagocytes, which in mice and man comprise two main subpopulations. Murine Ly6C+ monocytes display developmental plasticity and are recruited to complement tissue-resident macrophages and dendritic cells on demand. Murine vascular Ly6C- monocytes patrol the endothelium, act as scavengers, and support vessel wall repair. Here we characterized population and single...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 28514690
DOI: 10.1016/j.immuni.2017.04.018

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