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IL-1β promotes MPN disease initiation by favoring early clonal expansion of <i>JAK2</i> -mutant hematopoietic stem cells

2023-05-22

Abstract excerpt

JAK2 -V617F is the most frequent somatic mutation causing myeloproliferative neoplasm (MPN). However, JAK2 -V617F can also be found in healthy individuals with clonal hematopoiesis of indeterminate potential (CHIP) with a frequency much higher than the prevalence of MPN. The factors controlling the conversion of JAK2 -V617F CHIP to MPN are largely unknown. We hypothesized that IL-1β mediated inflammation is one...

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Identifiers and source

Literature Corpus work
c96a2042-66fe-52c4-a83e-610df9471629
DOI
10.1101/2023.05.21.541610
Open publication

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IL-1β promotes MPN disease initiation by favoring early clonal expansion of <i>JAK2</i> -mutant hematopoietic stem cellsDOI 10.1101/2023.05.21.541610
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