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Single <i>JAK2</i> -V617F hematopoietic stem cells can initiate MPN in transplantations into non-conditioned recipient mice

2025-06-08

Abstract excerpt

<h4>ABSTRACT</h4> Myeloproliferative neoplasms (MPN) are clonal disorders of hematopoietic stem cells (HSC) that are most frequently caused by acquired somatic mutations in JAK2 . A number of conditional mouse models of JAK2- V617F-driven MPN have been generated that rely on Cre-LoxP mediated activation, resulting in polyclonal disease. To more closely mimic the monoclonal origin of human MPN, transplantations...

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Literature Corpus work
3761843d-273e-53a9-b07a-19a448f907b6
DOI
10.1101/2025.06.08.657469
Open publication

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Single <i>JAK2</i> -V617F hematopoietic stem cells can initiate MPN in transplantations into non-conditioned recipient miceDOI 10.1101/2025.06.08.657469
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