Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Clonal heterogeneity as a driver of disease variability in the evolution of myeloproliferative neoplasms.

Experimental hematology - 1 Oct 2014

Prick Janine, de Haan Gerald, Green Anthony R, Kent David G

Abstract excerpt

Myeloproliferative neoplasms (MPNs) are clonal hematological diseases in which cells of the myelo-erythroid lineage are overproduced and patients are predisposed to leukemic transformation. Hematopoietic stem cells are the suspected disease-initiating cells, and these cells must acquire a clonal advantage relative to nonmutant hematopoietic stem cells to perpetuate disease. In 2005, several groups identified a...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Clone Cells
Share to Gene Knock-In Techniques
Share to Hematopoietic Stem Cells

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Janus Kinase 2

Share to Leukemia, Myeloid

Share to Multipotent Stem Cells

Share to Myeloproliferative Disorders

Share to Neoplastic Stem Cells

Source

Identifiers

PMID: 25201757
DOI: 10.1016/j.exphem.2014.07.268

Genes

JAK2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Clonal heterogeneity as a driver of disease variability in the evolution of myeloproliferative neoplasms.PMID 25201757Read ↗

Clonal architecture evolution in Myeloproliferative Neoplasms: from a driver mutation to a complex heterogeneous mutational and phenotypic landscape.Semantic proximity Read ↗

[Clonal evolution in myeloproliferative neoplasms].Semantic proximity Read ↗

Molecular basis and clonal evolution of myeloproliferative neoplasms.Semantic proximity Read ↗

Clonal Hematopoiesis and Evolution to Hematopoietic Malignancies.Semantic proximity Read ↗

[Clonal evolution of myeloid malignancies].Semantic proximity Read ↗

Self-renewal of single mouse hematopoietic stem cells is reduced by JAK2V617F without compromising progenitor cell expansion.Semantic proximity Read ↗

The JAK2 mutation.Semantic proximity Read ↗

The lifelong natural history of clonal hematopoiesis and its links to myeloid neoplasia.Semantic proximity Read ↗

Pathogenesis and management of high molecular risk myeloproliferative neoplasmsSemantic proximity Read ↗

Genetic and epigenetic complexity in myeloproliferative neoplasms.Semantic proximity Read ↗

Modeling myeloproliferative neoplasms: From mutations to mouse models and back again.Semantic proximity Read ↗

Clonal Hematopoiesis: Origins and determinants of evolution.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.