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Article

The hematopoietic stem cell compartment of JAK2V617F-positive myeloproliferative disorders is a reflection of disease heterogeneity.

Blood - 15 Sept 2008

James Chloe, Mazurier Frederic, Dupont Sabrina, Chaligne Ronan, Lamrissi-Garcia Isabelle, Tulliez Micheline, Lippert Eric, Mahon François-Xavier, Pasquet Jean-Max, Etienne Gabriel, Delhommeau François, Giraudier Stephane, Vainchenker William, de Verneuil Hubert

Abstract excerpt

The JAK2V617F somatic point mutation has been described in patients with myeloproliferative disorders (MPDs). Despite this progress, it remains unknown how a single JAK2 mutation causes 3 different MPD phenotypes, polycythemia vera (PV), essential thrombocythemia, and primitive myelofibrosis (PMF). Using an in vivo xenotransplantation assay in nonobese diabetic-severe combined immunodeficient (NOD/SCID) mice, we...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 18612101
DOI: 10.1182/blood-2008-02-137877

Genes

JAK2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The hematopoietic stem cell compartment of JAK2V617F-positive myeloproliferative disorders is a reflection of disease heterogeneity.PMID 18612101Read ↗

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IL-1β promotes MPN disease initiation by favoring early clonal expansion of JAK2 -mutant hematopoietic stem cellsSemantic proximity Read ↗

Genome editing to model and reverse a prevalent mutation associated with myeloproliferative neoplasmsSemantic proximity Read ↗

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