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Article

Myeloproliferative neoplasms can be initiated from a single hematopoietic stem cell expressing JAK2-V617F.

The Journal of experimental medicine - 20 Oct 2014

Lundberg Pontus, Takizawa Hitoshi, Kubovcakova Lucia, Guo Guoji, Hao-Shen Hui, Dirnhofer Stephan, Orkin Stuart H, Manz Markus G, Skoda Radek C

Abstract excerpt

The majority of patients with myeloproliferative neoplasms (MPNs) carry a somatic JAK2-V617F mutation. Because additional mutations can precede JAK2-V617F, it is questioned whether JAK2-V617F alone can initiate MPN. Several mouse models have demonstrated that JAK2-V617F can cause MPN; however, in...

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Source

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Identifiers

PMID: 25288396
DOI: 10.1084/jem.20131371
PMCID: PMC4203945

Genes

JAK2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-25288396-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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Myeloproliferative neoplasms can be initiated from a single hematopoietic stem cell expressing JAK2-V617F.PMID 25288396Read ↗

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