Article

<i>JAK2</i> <sup>V617F</sup> Myeloproliferative Neoplasms Support Parallel Evolution of Independent Leukemic Clones

2025-09-25

Abstract excerpt

Myeloproliferative neoplasms (MPNs) are hematological diseases predominantly driven by the JAK2 V617F mutation. Progression from chronic-phase MPN to secondary acute myeloid leukemia (sAML) is a severe complication that dramatically worsens disease prognosis. While progression to sAML is classically linked to MPN clones acquiring additional mutations, the absence of JAK2 V617F in some cases of post-MPN sAML case...

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Literature Corpus work: ed7e6db7-2d91-58d2-8382-d65b9ecd0707
DOI: 10.1101/2025.09.23.678057

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