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Article

The role of cell location and spatial gradients in the evolutionary dynamics of colon and intestinal crypts.

Biology direct - 23 Aug 2016

Shahriyari Leili, Komarova Natalia L, Jilkine Alexandra

Abstract excerpt

BACKGROUND: Colon and intestinal crypts serve as an important model system for adult stem cell proliferation and differentiation. We develop a spatial stochastic model to study the rate of somatic evolution in a normal crypt, focusing on the production of two-hit mutants that inactivate a tumor suppressor gene. We investigate the effect of cell division pattern along the crypt on mutant production, assuming that...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 27549762
DOI: 10.1186/s13062-016-0141-6
PMCID: PMC4994304

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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