Article
Stochastic model for cell population dynamics quantifies homeostasis in colonic crypts and its disruption in early tumorigenesis
2023-03-23
Abstract excerpt
The questions of how healthy colonic crypts maintain their size, and how homeostasis is disrupted by driver mutations, are central to understanding colorectal tumorigenesis. We propose a three-type stochastic branching process, which accounts for stem, transit-amplifying (TA) and fully differentiated (FD) cells, to model the dynamics of cell populations residing in colonic crypts. Our model is simple in its formul...
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Identifiers and source
- Literature Corpus work
- f7162cdf-de31-5e85-a4f7-80862ebbfef8
- DOI
- 10.1101/2023.03.19.533357