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Article

Modeling of stem cell dynamics in human colonic crypts in silico.

Journal of gastroenterology - 1 Feb 2014

Kagawa Yuki, Horita Noriko, Taniguchi Hideki, Tsuneda Satoshi

Abstract excerpt

BACKGROUND: Several possible scenarios of cellular dynamics in human colonic crypts have been inferred from transgenic animal experiments. However, because of the discrepancy in size and physiology between humans and animals, quantitative predictions of tissue renewal and cancer development are difficult to execute. METHODS: A two-dimensional individual based model was developed for the first time to predict...

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PMID: 24077809
DOI: 10.1007/s00535-013-0887-x

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