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Article

Mathematical modeling of multiple pathways in colorectal carcinogenesis using dynamical systems with Kronecker structure.

PLoS computational biology - 1 May 2021

Haupt Saskia, Zeilmann Alexander, Ahadova Aysel, Bläker Hendrik, von Knebel Doeberitz Magnus, Kloor Matthias, Heuveline Vincent

Abstract excerpt

Like many other types of cancer, colorectal cancer (CRC) develops through multiple pathways of carcinogenesis. This is also true for colorectal carcinogenesis in Lynch syndrome (LS), the most common inherited CRC syndrome. However, a comprehensive understanding of the distribution of these pathways of carcinogenesis, which allows for tailored clinical treatment and even prevention, is still lacking. We suggest a...

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Identifiers

PMID: 34003820
DOI: 10.1371/journal.pcbi.1008970
PMCID: PMC8162698

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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