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Article

A calibrated agent-based computer model of stochastic cell dynamics in normal human colon crypts useful for in silico experiments.

Theoretical biology & medical modelling - 18 Nov 2013

Bravo Rafael, Axelrod David E

Abstract excerpt

BACKGROUND: Normal colon crypts consist of stem cells, proliferating cells, and differentiated cells. Abnormal rates of proliferation and differentiation can initiate colon cancer. We have measured the variation in the number of each of these cell types in multiple crypts in normal human biopsy specimens. This has provided the opportunity to produce a calibrated computational model that simulates cell dynamics in...

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Identifiers

PMID: 24245614
DOI: 10.1186/1742-4682-10-66
PMCID: PMC3879123

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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