Article

Temporal Genomic Dynamics Shape Clinical Trajectory in Multiple Myeloma

2024-09-04

Abstract excerpt

<h4>ABSTRACT</h4> To comprehensively unravel the temporal relationship between initiating and driver events and its impact on clinical outcomes, we analyzed 421 whole-genome sequencing profiles from 382 patients. Using clock-like mutational signatures, we estimated a time lag of 2-4 decades between initiating events and diagnosis. In patients with hyperdiploidy, we demonstrate that trisomies of odd-numbered chrom...

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Literature Corpus work: c934be3f-dfb8-5778-90f2-b8373de0571b
DOI: 10.1101/2024.08.30.610457

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