Article
Development of hyperdiploidy starts at an early age and takes a decade to complete.
Blood - 30 Jan 2025
Samur Mehmet K, Aktas Samur Anil, Shah Parth, Park Joseph S, Fulciniti Mariateresa, Shammas Masood, Corre Jill, Anderson Kenneth C, Parmigiani Giovanni, Avet-Loiseau Hervé, Munshi Nikhil C
Abstract excerpt
ABSTRACT: Nearly half of patients with multiple myeloma (MM) have hyperdiploidy (HMM) at diagnosis. Although HMM occurs early, the mutational processes before and after hyperdiploidy are still unclear. Here, we used 72 whole-genome sequencing samples from patients with HMM and identified pre- and post-HMM mutations to define the chronology of the development of hyperdiploidy. An MM cell accumulated a median of...
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