Genome instability in multiple myeloma.

doi:10.1038/s41375-020-0921-y

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Article

Genome instability in multiple myeloma.

Leukemia - 1 Nov 2020

Neuse Carl Jannes, Lomas Oliver C, Schliemann Christoph, Shen Yu Jia, Manier Salomon, Bustoros Mark, Ghobrial Irene M

Abstract excerpt

Multiple myeloma (MM) is an incurable plasma cell malignancy characterized by clonal proliferation of plasma cells and a heterogenous genomic landscape. Copy number and structural changes due to chromosomal instability (CIN) are common features of MM. In this review, we describe how primary and secondary genetic events caused by CIN can contribute to increased instability across the genome of malignant plasma...

Topics

Animals
Chromosomal Instability
DNA Copy Number Variations
Genetic Association Studies
Genetic Predisposition to Disease
Genomic Instability
Humans
Multiple Myeloma
Mutation
Tumor Microenvironment

Source

Open in PubMed

Identifiers

PMID: 32651540
DOI: 10.1038/s41375-020-0921-y

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