Article
Genomic landscape and chronological reconstruction of driver events in multiple myeloma
2018-08-12
Abstract excerpt
Multiple myeloma (MM) has a heterogeneous genome, evolving through both pre-clinical and post-diagnosis phases. Here, using sequences from 67 MM genomes serially collected from 30 patients together with public datasets, we establish a hierarchy of driver lesions. Point mutations, structural variants and copy number aberrations define at least 7 genomic subgroups of MM, each with distinct sets of co-operating drive...
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Identifiers and source
- Literature Corpus work
- 99b3ce17-ce0d-57ca-986b-c4e3f9fe5d52
- DOI
- 10.1101/388611