Timing the initiation of multiple myeloma.

doi:10.1038/s41467-020-15740-9

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Article

Timing the initiation of multiple myeloma.

Nature communications - 21 Apr 2020

Rustad Even H, Yellapantula Venkata, Leongamornlert Daniel, Bolli Niccolò, Ledergor Guy, Nadeu Ferran, Angelopoulos Nicos, Dawson Kevin J, Mitchell Thomas J, Osborne Robert J, Ziccheddu Bachisio, Carniti Cristiana, Montefusco Vittorio, Corradini Paolo, Anderson Kenneth C, Moreau Philippe, Papaemmanuil Elli, Alexandrov Ludmil B, Puente Xose S, Campo Elias, Siebert Reiner, Avet-Loiseau Herve, Landgren Ola, Munshi Nikhil, Campbell Peter J, Maura Francesco

Abstract excerpt

The evolution and progression of multiple myeloma and its precursors over time is poorly understood. Here, we investigate the landscape and timing of mutational processes shaping multiple myeloma evolution in a large cohort of 89 whole genomes and 973 exomes. We identify eight processes, including a mutational signature caused by exposure to melphalan. Reconstructing the chronological activity of each mutational...

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Identifiers

PMID: 32317634
DOI: 10.1038/s41467-020-15740-9
PMCID: PMC7174344

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

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