Temporal genomic dynamics shape clinical trajectory in multiple myeloma.

doi:10.1038/s41588-025-02292-1

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Article

Temporal genomic dynamics shape clinical trajectory in multiple myeloma.

Nature genetics - 1 Sept 2025

Maura Francesco, Kaddoura Marcella, Poos Alexandra M, Baughn Linda B, Ziccheddu Bachisio, Bärtsch Marc-Andrea, Cirrincione Anthony, Maclachlan Kylee, Chojnacka Monika, Diamond Benjamin, Papadimitriou Marios, Blaney Patrick, John Lukas, Reichert Philipp, Huhn Stefanie, Gagler Dylan, Zhang Yanming, Dogan Ahmet, Lesokhin Alexander M, Davies Faith, Goldschmidt Hartmut, Fenk Roland, Weisel Katja C, Mai Elias K, Korde Neha, Morgan Gareth J, Rajkumar S Vincent, Kumar Shaji, Usmani Saad, Landgren Ola, Raab Marc S, Weinhold Niels

Abstract excerpt

Multiple myeloma evolution is characterized by the accumulation of genomic drivers over time. To unravel this timeline and its impact on clinical outcomes, we analyzed 421 whole-genome sequences from 382 patients. Using clock-like mutational signatures, we estimated a time lag of two to four decades between the initiation of events and diagnosis. We demonstrate that odd-numbered chromosome trisomies in patients...

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Identifiers

PMID: 40835892
DOI: 10.1038/s41588-025-02292-1
PMCID: PMC13127375

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