Article

<i>Leptin</i> deficient rats develop nonalcoholic steatohepatitis with unique disease progression

2019-04-05

Abstract excerpt

Nonalcoholic steatohepatitis (NASH) is an aggressive liver disease threatening public health, however its natural history is poorly understood. Unlike ob/ob mice, Lep ∆I14/∆I14 rats develop unique NASH phenotype with steatosis, lymphocyte infiltration and ballooning after postnatal week 16. Using Lep ∆I14/∆I14 rats as NASH model, we studied the natural history of NASH progression by performing an integrated a...

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Literature Corpus work: c92b2148-6a5f-55cd-acd8-3c62494767e8
DOI: 10.1101/594978

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