Article
Long-term hypercaloric diet exacerbates metabolic liver disease in PNPLA3 I148M animals.
Liver international : official journal of the International Association for the Study of the Liver - 1 Aug 2023
Su Huan, Haque Madhuri, Becker Svea, Edlund Karolina, Duda Julia, Wang Qingbi, Reißing Johanna, Marschall Hanns-Ulrich, Candels Lena S, Mohamed Mohamed, Sjöland Wilhelm, Liao Lijun, Drexler Stephan A, Strowig Till, Rahnenführer Jörg, Hengstler Jan G, Hatting Maximilian, Trautwein Christian
Abstract excerpt
BACKGROUND & AIMS: Nonalcoholic fatty liver disease (NAFLD) is a major health burden associated with the metabolic syndrome leading to liver fibrosis, cirrhosis and ultimately liver cancer. In humans, the PNPLA3 I148M polymorphism of the phospholipase patatin-like phospholipid domain containing protein 3 (PNPLA3) has a well-documented impact on metabolic liver disease. In this study, we used a mouse model...
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