Article
Macrophage Phenotypes and Gene Expression Patterns Are Unique in Naturally Occurring Metabolically Healthy Obesity.
International journal of molecular sciences - 21 Oct 2022
Ruggiero Alistaire D, Vemuri Ravichandra, Block Masha, DeStephanis Darla, Davis Matthew, Chou Jeff, Williams Abigail, Brock Ashlynn, Das Swapan Kumar, Kavanagh Kylie
Abstract excerpt
Obesity impacts 650 million individuals globally, often co-occurring with metabolic syndrome. Though many obese individuals experience metabolic abnormalities (metabolically unhealthy obese [MUO]), ~30% do not (metabolically healthy obese [MHO]). Conversely, >10% of lean individuals are metabolically unhealthy (MUL). To evaluate the physiologic drivers of these phenotypes, a 44-animal African green monkey cohort...
Topics
- Animals
- Chlorocebus aethiops
- Obesity, Metabolically Benign
- Metabolic Syndrome
- Endothelial Cells
- Obesity
- Phenotype
- Macrophages
- Lipids
- Cytokines