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Article

Characterizing disease progression of nonalcoholic steatohepatitis in Leptin-deficient rats by integrated transcriptome analysis.

Experimental biology and medicine (Maywood, N.J.) - 1 Mar 2021

Lu Ping, Yang Guang, Jiang Lichun, He Wen, Wu Wanwan, Qi Lingbin, Shen Shijun, Rao Junhua, Zhang Peng, Xue Zhigang, Jiang Cizhong, Fan Guoping, Zhu Xianmin

Abstract excerpt

Nonalcoholic steatohepatitis (NASH) is an aggressive liver disease threatening human health, yet no medicine is developed to treat this disease. In this study, we first discovered that Leptin mutant rats (LepΔI14/ΔI14) exhibit characteristic NASH phenotypes including steatosis, lymphocyte infiltration, and ballooning after postnatal week 16. We then examined NASH progression by performing an integrated analysis...

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Disease Progression
Gene Expression Profiling
Inflammation
Leptin
Liver

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Non-alcoholic Fatty Liver Disease

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Identifiers

PMID: 33302736
DOI: 10.1177/1535370220976530
PMCID: PMC7988730

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