Back to search

Article

Characterization of the metabolic pathways and hepatic macrophage subsets in mouse models of MASH

2024-11-23

Abstract excerpt

<title>Abstract</title> <p>Background Metabolic dysfunction-associated steatohepatitis (MASH), a more severe subtype of Metabolic dysfunction-associated steatotic liver disease (MASLD), can lead to cirrhosis and hepatocellular carcinoma. Monocyte-derived macrophages (MDMs) play a central role in NASH. Single-cell and spatial transcriptomic technologies have revealed that MDMs react to niche-specific and inflamma...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
50c07084-3f0f-5e54-a438-e7c53e4b04fb
DOI
10.21203/rs.3.rs-5395060/v1
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Characterization of the metabolic pathways and hepatic macrophage subsets in mouse models of MASHDOI 10.21203/rs.3.rs-5395060/v1
Understanding Macrophage Complexity in Metabolic Dysfunction-associated Steatotic Liver Disease: Transitioning from the M1/M2 Paradigm to Spatial DynamicsSemantic proximity
Understanding Macrophage Complexity in Metabolic Dysfunction-Associated Steatotic Liver Disease: Transitioning from the M1/M2 Paradigm to Spatial DynamicsSemantic proximity
Kupffer Cells Undergo Fundamental Changes during the Development of Experimental NASH and Are Critical in Initiating Liver Damage and InflammationSemantic proximity
Understanding the Heterogeneity of Resident Liver Macrophages.Semantic proximity
YAP activation in liver macrophages via depletion of MST1/MST2 enhances liver inflammation and fibrosis in MASLDSemantic proximity
Metabolic Rewiring in MASLD: From Disease Mechanisms to Precision MedicineSemantic proximity
Human-Mouse Convergence in Metabolic Dysfunction-Associated Steatotic Liver Disease: Mouse Model Selection and Non-Invasive Diagnostic StrategiesSemantic proximity
Sex- and hepatocyte PPARγ-dependent effects of an obesogenic dietary approach to induce MASH with fibrosis in miceSemantic proximity
Association of lipids in lipoprotein subfractions with liver fibrosis in a mouse model of metabolic dysfunction–associated steatohepatitisSemantic proximity
Intrahepatic Macrophage Reprogramming Associated with Lipid Metabolism in Hepatitis B Virus-Related Acute-on-Chronic Liver FailureSemantic proximity
Macrophage functional diversity in NAFLD — more than inflammationSemantic proximity
Differences in metabolic and liver pathobiology induced by two dietary mouse models of nonalcoholic fatty liver diseaseSemantic proximity
Select a neighboring publication to make it the new centre.