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Article

The Transcriptomic Signature Of Disease Development And Progression Of Nonalcoholic Fatty Liver Disease

4 Dec 2017

Abstract excerpt

A longitudinal molecular model of the development and progression of nonalcoholic fatty liver disease (NAFLD) over time is lacking. We have recently validated a high fat/sugar water-induced animal (an isogenic strain of C57BL/6 J:129S1/SvImJ mice) model of NAFLD that closely mimics most aspects of human disease. The hepatic transcriptome of such mice with fatty liver (8 weeks), steatohepatitis with early fibrosis...

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PMID: 29222421
DOI: 10.1038/s41598-017-17370-6

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